Recommended Starting Dose
The recommended starting dose of Inspra (eplerenone) is 50 mg administered once daily. The full therapeutic effect is typically seen within 4 weeks. For patients with inadequate blood pressure response to 50 mg, titration may be necessary.
Dosage Adjustments Based on Condition
Patients with essential hypertension typically start with a 50 mg dose of Inspra, which can be increased to a maximum of 100 mg daily. For heart failure post-myocardial infarction, the initial dose is 25 mg once daily, titrated to 50 mg once daily. Dosage adjustments are based on individual response and tolerability.
Dosing for Essential Hypertension
The recommended starting dose for essential hypertension with Inspra is 50 mg once daily, which may be titrated to a maximum of 50 mg twice daily based on individual response. The full therapeutic effect of Inspra usually becomes apparent within 4 weeks of treatment initiation.
Dosing for Heart Failure Post-Myocardial Infarction
For patients post-myocardial infarction with heart failure, the recommended starting dose of Inspra is 25 mg once daily, which should be titrated to 50 mg once daily within 4 weeks as tolerated. Dose adjustments may be required based on serum potassium levels during treatment.
Combination Therapy and Dosage
When used in combination therapy, Inspra is typically administered once daily at a recommended starting dose of 50 mg. For optimal therapeutic benefits, the dosage may be increased to 50 mg twice daily if necessary. Close monitoring of the patient’s response is essential to determine the most effective regimen.
Monitoring and Titration
Regular monitoring of patients receiving Inspra is essential to assess the therapeutic response and manage potential side effects. Titration based on individual patient response is crucial to optimize treatment outcomes while minimizing adverse effects. Serum potassium levels should be closely monitored during therapy.
Potential Side Effects
When taking Inspra, some potential side effects may occur. These can include a light-headed feeling, gastrointestinal symptoms like diarrhea and vomiting, changes in urination, heart rhythm abnormalities, breathing difficulties, lower limb swelling, and high levels of potassium in the blood. If any severe side effects are experienced, immediate medical attention is advised.
Prevention of Hyperkalemia
To prevent hyperkalemia when administering Inspra, appropriate patient selection is crucial. Avoiding concomitant treatments that may elevate potassium levels is essential. Patients should be thoroughly informed about the risks, and regular monitoring of serum potassium levels is required until the effects of Inspra are established.
Forms and Cost of Inspra
Inspra is available in tablet form with strengths of 25 mg, 50 mg, and 100 mg. The approximate monthly cost for this medication varies based on the dosage form prescribed. Patients can consult their healthcare provider or pharmacist for specific pricing information based on their prescribed dose.
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