Overview of Arava
Leflunomide, sold under the brand name Arava, is a non-biologic, disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid arthritis in adults. It works by affecting the immune system to reduce swelling and inflammation. Arava is available in tablet form and is typically taken orally once a day. Patients should be monitored closely due to the potential for various side effects, including liver damage. It is crucial not to use Arava during pregnancy to avoid harm to the unborn baby.
Contraindications and Warnings
Arava has contraindications and warnings that are essential to consider before starting treatment. It is crucial to exclude pregnancy before initiating Arava therapy, as the medication can harm the unborn baby. Arava is contraindicated in pregnant women and in women of childbearing potential who are not using reliable contraception. Additionally, Arava carries a boxed warning due to the risk of severe liver damage, emphasizing the need for monitoring liver function during treatment.
Use During Pregnancy
It is crucial to avoid using Arava if you are pregnant or suspect you might be pregnant. The medication can cause harm to the unborn baby and is contraindicated in pregnant women and in women of childbearing potential not using reliable contraception. Using Arava during pregnancy or before completing the drug elimination procedure can result in severe liver injury and should be strictly avoided.
Accelerated Drug Elimination Procedure
After stopping Arava, it is recommended to undergo an accelerated drug elimination procedure to decrease plasma concentrations. This procedure helps in lowering the levels of the medication in the body. Severe infections, pancytopenia, agranulocytosis, and thrombocytopenia are among the serious adverse effects that may require prompt action, including stopping Arava and implementing the accelerated elimination procedure.
Severe Side Effects
While taking Arava, patients should be aware of potential severe side effects that may occur. These include serious liver damage, severe infections, pancytopenia, agranulocytosis, and thrombocytopenia. If any of these side effects are experienced, it is crucial to seek immediate medical attention and potentially discontinue the medication.
Liver Damage Risk
Arava poses a risk of severe liver damage, including fatal liver failure, which underscores the importance of close monitoring while on this medication. It is crucial to be vigilant for signs of liver problems and promptly report any symptoms like jaundice, nausea, abdominal pain, or unusual fatigue to your healthcare provider. Patients with preexisting liver conditions or elevated liver enzymes should exercise caution when considering Arava treatment.
Other Precautions
Additional precautions to consider while taking Arava include informing your healthcare provider about any history of kidney disease, liver disease, diabetes, infections, lung disease, tuberculosis, or blood or bone marrow problems. It is essential to discuss your medical history thoroughly to ensure the safe and effective use of Arava and to monitor for any potential complications.
Boxed Warning
Arava carries a boxed warning due to the risk of severe liver damage, including potentially fatal liver failure. This serious warning alerts both healthcare providers and patients about the potential dangers associated with the medication. It is crucial to be aware of this risk and to monitor liver function closely while using Arava.
Adverse Reactions
When taking Arava, patients may experience common adverse reactions such as diarrhea, elevated liver enzymes, alopecia, and rash. Monitoring for these side effects is important during Arava treatment to address any potential concerns promptly.
Interactions and Allergies
When taking Arava, it is essential to inform your healthcare provider about any allergies you have, especially if you are allergic to leflunomide or any other ingredients in the medication. Additionally, discuss any medications, supplements, or herbal products you are currently taking to avoid potential interactions that could impact the effectiveness or safety of Arava.
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