General Instructions for Use
Wellbutrin SR (bupropion hydrochloride) is an FDA-approved medication primarily used to treat major depressive disorder and seasonal affective disorder. The recommended adult dose is 300 mg/day‚ taken as 150 mg twice daily. It is essential to start with a lower dose and gradually increase after a few days. Wellbutrin SR can be taken with or without food‚ but dosages should be spaced at least 8 hours apart. Avoid taking a dose before bedtime. Keep in mind the maximum daily dose should not exceed 300 mg. For the best results‚ follow your healthcare provider’s guidance on dosage and administration.
Dosage for Major Depressive Disorder (MDD)
For the treatment of Major Depressive Disorder (MDD) with Wellbutrin SR‚ the typical adult target dose is 300 mg/day‚ administered as 150 mg twice daily. Initially‚ start with 150 mg/day as a single dose in the morning. After 3 days‚ the dose may be increased to the target 300 mg/day‚ given as 150 mg twice daily. It is crucial to maintain an interval of at least 8 hours between consecutive doses. The maximum daily dose should not exceed 300 mg to ensure optimal effectiveness and safety in managing MDD symptoms.
Dosage for Seasonal Affective Disorder (SAD)
The typical adult target dose for Wellbutrin SR in treating Seasonal Affective Disorder (SAD) is 300 mg/day‚ given as 150 mg twice daily. Treatment usually begins with a 150 mg/day dose as a single morning dose for the first 3 days‚ which may then be escalated to the 300 mg/day target dose after the initial period. It is crucial to maintain an interval of at least 8 hours between successive doses for effective management of SAD symptoms.
Switching Patients from WELLBUTRIN Tablets or from WELLBUTRIN SR Sustained-Release Tablets
When transitioning patients from WELLBUTRIN Tablets or WELLBUTRIN SR Sustained-Release Tablets to Wellbutrin SR‚ maintain a maximum total daily dose of 300 mg. Begin with 150 mg/day as a single morning dose before escalating to the target 300 mg/day‚ taken as 150 mg twice daily. It is crucial to ensure there is at least an 8-hour interval between doses for optimal effectiveness and safety during the switching process.
To Discontinue Wellbutrin XL‚ Taper the Dose
When discontinuing Wellbutrin XL‚ it is crucial to taper the dose gradually under the supervision of a healthcare professional. Abruptly stopping the medication can lead to withdrawal symptoms and potential adverse effects. Your doctor will provide a tapering schedule to safely reduce your dosage over time. This method helps minimize the risk of withdrawal symptoms and ensures a smooth transition off Wellbutrin XL.
Dose Adjustment in Patients with Hepatic Impairment
When considering patients with hepatic impairment‚ it is important to note that the usual adult target dose for Wellbutrin SR is 300 mg/day‚ administered as 150 mg twice daily. Initiate dosing with 150 mg/day as a single dose in the morning‚ which may be increased to the target 300 mg/day after 3 days. Patients with hepatic impairment should follow dosage adjustments recommended by their healthcare provider to ensure safe and effective treatment.
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