Dosage and Administration
Adults are typically prescribed 100 mg of aceclofenac twice daily, with one tablet in the morning and one in the evening. The duration of treatment is determined individually by a healthcare provider. For patients with moderate liver impairment, the dosage of aceclofenac should be reduced. The recommended initial daily dose is 100 mg.
Studies have shown better safety profile for aceclofenac at double the dose compared to diclofenac, with lower incidence of gastrointestinal and cardiovascular side effects. Aceclofenac is commonly used for symptomatic treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
Aceclofenac, a nonsteroidal anti-inflammatory drug, exerts anti-inflammatory, analgesic, and antipyretic effects. It is also indicated for various conditions such as low back pain, dental pain, soft tissue rheumatic disorders, and more.
Indications
Aceclofenac is commonly prescribed for symptomatic treatment of conditions like rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also used to alleviate inflammation and pain associated with low back pain, dental pain, and soft tissue rheumatic disorders. This nonsteroidal anti-inflammatory drug (NSAID) exerts anti-inflammatory, analgesic, and antipyretic effects, making it a versatile option for various inflammatory conditions.
Mechanism of Action
The drug aceclofenac, a nonsteroidal anti-inflammatory drug (NSAID), exhibits anti-inflammatory, analgesic, and antipyretic effects by inhibiting the enzyme cyclooxygenase (COX), which leads to decreased synthesis of prostaglandins. Prostaglandins are lipid compounds that promote inflammation, pain, and fever. By blocking their production, aceclofenac effectively reduces inflammation, alleviates pain, and lowers fever in various inflammatory conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
Adverse Effects
Common adverse effects associated with aceclofenac include gastrointestinal issues like dyspepsia, stomach pain, and diarrhea. Less frequently observed side effects may involve skin reactions such as itching, rash, and dermatitis. In some cases, patients may experience elevated liver enzymes. Additionally, there have been reports of kidney-related adverse effects with the prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) like aceclofenac. If any of these side effects persist or worsen, it is crucial to promptly inform a healthcare provider for further evaluation and management.
Regulatory Updates
In a recent development, the Indian government has taken a significant step by banning the veterinary use of ketoprofen and aceclofenac. This decision comes amid concerns about the adverse impact of these drugs on vultures and their role in the ecosystem. Such regulatory measures aim to safeguard not only animal health but also the environment. Stay informed about updates regarding the pharmaceutical regulations to ensure compliance and promote the responsible use of medications.
Leave a Reply