Adult Dosage⁚ Initiate with 200mg once daily for 14 days, then switch to 400mg once daily. Pediatric Patients⁚ Dosage based on body surface area.
Adult Dosage
Adult Dosage⁚ Initiate with 200mg once daily for 14 days, then switch to 400mg once daily. If a mild-to-moderate rash develops during the 14-day lead-in period, do not start Viramune XR until the rash resolves. The lead-in period is not necessary if the patient is already on a regimen of immediate-release Viramune twice daily.
Pediatric Dosage
Pediatric Patients⁚ Dosing based on body surface area (BSA) calculated using the Mosteller formula. All pediatric patients must initiate therapy with immediate-release Viramune (as 150 mg/m2 of Viramune Oral Suspension or as Viramune tablets), at a dose not to exceed 200 mg per day, administered once daily for the first 14 days. After the 14-day lead-in period, switch to Viramune XR 400 mg once daily. Adjustments may be needed based on patient’s condition.
Administration Guidelines
Adult Dosage⁚ Swallow the tablets whole. 18 years and older should take 200mg of Viramune once daily initially for 14 days, then switch to 400mg of Viramune XR once daily. Do not chew or crush the tablets.
Swallowing Instructions
Swallow Viramune XR extended-release tablets whole without chewing, crushing, or dividing. In case of a missed dose, take it as soon as remembered. If close to the next dose, do not double up. Always follow prescribed dosing instructions.
Missed Dose Guidelines
If a dose of Viramune XR is missed, patients should take it as soon as remembered unless it is almost time for the next dose. In that case, patients should skip the missed dose and resume their usual dosing schedule. Doubling up on doses is not recommended. Consistent adherence to the prescribed dosing schedule is crucial for treatment effectiveness.
Considerations and Precautions
Viramune XR should be taken daily as prescribed without missing doses to maintain treatment effectiveness. Rash during lead-in phase should be monitored. Patients must not double up on missed doses.
Side Effects and Warning Signs
Viramune XR can cause severe allergic reactions with symptoms like joint or muscle pain, fever, facial swelling, blistering skin rash, swollen glands, weakness, tingling, difficulty urinating, swelling in limbs, chest pain, trouble breathing, or swelling in lips or tongue. Immediate medical help is necessary in case of such reactions.
Special Population Considerations
For pediatric patients, dosing of Viramune XR is based on body surface area calculated using the Mosteller formula. Initiating therapy with immediate-release Viramune is essential, followed by Viramune XR based on individual patient factors and response to treatment. The dosing regimen should be carefully tailored to each pediatric patient’s specific needs to ensure optimal treatment outcomes.
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